I've been trying Palmitoylethanolamide which is a studied alternative but it takes many weeks for it to start working as it has to build up in fat stores, can't say I feel anything from it yet after eight weeks
stevenalowe 20 hours ago [-]
sigh - in mice.
donkey_brains 19 hours ago [-]
This explains a lot about that mouse who got a cookie and subsequently wanted a lot of other food
ck2 8 hours ago [-]
well they have to start somewhere, bringing new medical drugs to market is a decade long project
and even worse it has to be profitable even if it works to make it to production
I searched clinicaltrials.gov for geraniol and there is sadly nothing
I'll have to try to email the researchers to see what they are up to next
Maybe geraniol can be extracted from other plants that are not on any federal drug schedules, that would change everything and allow it to be marketed as a food supplement which would effectively not have any regulation at all
ps. chatgpt says Geraniol is abundant in rose oil, palmarosa oil, citronella oil, and lemongrass oil
which gives other legal OTC options
it also points out they used a MASSIVE dose in the mice to get just a few hours of pain relief
there is also a legally prescribed medication called Istradefylline that does the same thing as Geraniol
pps. ChatGPT also says Palmitoylethanolamide is likely far more effective than Geraniol (and Palmitoylethanolamide is already legal as OTC supplement)
* https://pmc.ncbi.nlm.nih.gov/articles/PMC11974608/
* https://link.springer.com/article/10.1007/s43440-024-00687-1
previous study from 2021
* https://www.nature.com/articles/s41598-021-87740-8
but it is fascinating
I've been trying Palmitoylethanolamide which is a studied alternative but it takes many weeks for it to start working as it has to build up in fat stores, can't say I feel anything from it yet after eight weeks
and even worse it has to be profitable even if it works to make it to production
I searched clinicaltrials.gov for geraniol and there is sadly nothing
I'll have to try to email the researchers to see what they are up to next
Maybe geraniol can be extracted from other plants that are not on any federal drug schedules, that would change everything and allow it to be marketed as a food supplement which would effectively not have any regulation at all
ps. chatgpt says Geraniol is abundant in rose oil, palmarosa oil, citronella oil, and lemongrass oil
which gives other legal OTC options
it also points out they used a MASSIVE dose in the mice to get just a few hours of pain relief
there is also a legally prescribed medication called Istradefylline that does the same thing as Geraniol
pps. ChatGPT also says Palmitoylethanolamide is likely far more effective than Geraniol (and Palmitoylethanolamide is already legal as OTC supplement)